Endocrine Abstracts

Introduction: Pancreatic ACTHomas have a poor prognosis with severe and rapidly progressive clinical courses, influenced by hypercortisolaemia thus whenever possible, control of the cortisol levels should be obtained to reduce complications. We report the use of adrenal embolisation in a case of a life threatening paraneoplastic Cushing.Case: A 51-year-old woman with a negative past medical history complained of general weakness. Cushing’s syndrome ...

Introduction: Pheochromocytomas are a rare catecholamine secreting tumours that can mimic numerous stress-associated disorders, such as Takotsubo cardiomyopathy, or transient left ventricular apical ballooning which is brought on by an acute coronary vasospasm due to an excessive sympathetic stimulation.Case ReportA 68-year-old woman, with previous medical history of hypertension and type 2 diabetes, who was on 30 units of isuline ...

Introduction: Ectopic PTH secretion is rare, to our knowledge, with only 27 cases reported in the literature and 3, ( a tonsil, a lung and a penile) due to squamous cell carcinoma .In the few cases reported to date it appears to be more common in males and in those over the age of 60. The management of the hypercalcemia in this setting is complicated. We are aware of 2 other case reports in which cinacalcet was used in this context, but as in our case, unsuccessfully.<p cl...

Introduction: Although it has been suggested that there is a strong association between acromegaly and premalignant colonic lesions and colon cancer, it seems that in real – life practice the adherence to ACRO colonoscopy guidelines might be lower than expected (as recently shown by M.Parolin et cols).Methods: We retrospectively reviewed the case records of the 54 patients with acromegaly seen in our center since 1994.We analyzed the findings of 27 ...

Introduction: TSHomas are rare TSH producing tumors, whereas chronic autoimmune thyroiditis is a frequent condition. Patients with TSHoma are characterized by increased circulating levels of peripheral thyroid hormones, but when a chronic autoimmune thyroiditis is associated, they may be normal or low, making the diagnosis challenging.Case report: A 55 year-old woman, with previous medical history of obesity and impaired fasting glucose, was diagnosed of...

Introduction: Phaeocromocytomas are a rare catecholamine secreting tumours that can present in multiple ways. The classic triad of symptoms consists of episodic headache, sweating, and tachycardia. Most patients do not have the three classic symptoms. Sustained or paroxysmal hypertension is the most common sign. Among less common symptoms and signs constipation has been described and few cases of megacolon and phaeochromocytoma have been published.Case r...

Introduction: Acromegaly is an insidious disease caused by chronic GH and IGF-I hypersecretion associated with increased morbidity and mortality, mostly from cardiovascular complications. The aim of this study is to compare cardiovascular risk factors, between patients with medical treatment vs cured.Materials and methods: This is a retrospective study of 37 acromegalic patients, 21 well controlled with medical treatment (IGF-I within the normal range fo...

Background: The most common type of thyroid cancer is the well-differentiated thyroid carcinoma (DTC) and that includes papillary (PTC) and follicular carcinoma (FTC). The PTC would represent 50–90% and the FTC over 15–30%. Within the PTC, the most frequent is the classical variant (over 80%), followed by follicular variant (10%) and the rest of variants (<10%). Furthermore, there are differences between PTC and FTC in age at diagnosis, local extension, multicent...

Introduction: The presentation of new onset hyperandrogenism is extremely rare in postmenopausal women. In premenopausal women, the most common cause of androgen excess is polycystic ovary syndrome. In contrast, when hyperandrogenism develops in postmenopausal women, it is usually associated with other causes, such as ovarian hyperthecosis or an androgen secreting tumor. We describe 5 patients with hyperandrogenism (Table 1). Total Testosterone 0.06–0.86 ng/ml, free testo...

Introduction: Central diabetes insipidus (DI) is a common complication after pituitary surgery, but is transient in the majority of patients. The aim of our study is to determine the incidence and course of DI in the postoperative period and to characterize the factors associated with this disease.Methods: We performed a retrospective study of 44 patients (50% females) with a mean age of 54 years (24–83), treated with transsphenoidal (TSS) or transf...